Results: The results showed that the water extract of sea cucumber revealed remarkable anti-proliferative effect on CT26 tumor cells with IC 50= 31 µg/ml with recruitment of intrinsic apoptotic pathway in vitro. Swathi Muthyam Songs Free Download In South Mp3. In addition, the colon tumor volume in treated groups remarkably reduced in homozygous mice. Histopathological examination elucidated that sea cucumber extract attenuated tumor size and volume along with apoptosis characteristics. Moreover, RT-PCR analysis revealed that sea cucumber extract induced intrinsic apoptosis in vivo through suppression of Bcl-2 expression. Introduction Cancer is one of the deadly cause of morbidity in the worldwide that affected people’s lives and health ().

Colorectal carcinoma is the third most common form of cancer and the second leading reason of mortality among men and women globally which possess potency of extension to other parts of body including liver, lung, ovaries and other organs (). The increasing rate of colorectal cancer undertake because high smoking, lack of physical activities, overweight, obesity, processed meat consumption, and excessive alcohol consumption (). The conventional therapeutic methods for colon cancer therapy have been included surgery, chemotherapy with 5-fluorouracil alone or concurrent with irinotecan, oxaliplatin, panitumumab, cetuximab or bevacizumab and other remedies such as radiotherapy, targeted therapy and immunotherapy.