Contents • • • • • • • • Function [ ] Regulation of the p53 tumor suppressor [ ] USP7 or HAUSP is a specific or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation () is most commonly associated with the stability and degradation of cellular proteins, HAUSP activity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of, the for the tumor suppressor protein,. Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53.

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In response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. A possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.

Role in transcriptional regulation [ ] USP7 can deubiquitinate and this activity is associated with gene silencing in Drosophila. USP7 associates with a metabolic enzyme, GMP synthetase (GMPS) and this association stimulates USP7 deubiquitinase activity towards. The USP7-GMPS complex is recruited to the polycomb (Pc) region in Drosophila and contributes to epigenetic silecing of genes.

Association with herpesviruses [ ] USP7 was originally identified as a protein associated with the protein of (), hence the name Associated USP (HAUSP). ICP0 is an E3-ubiquitin ligase that is involved in ubiquitination and subsequent degradation of itself and certain cellular proteins. USP7 has been shown to regulate the auto-ubiquitination and degradation of ICP0. More recently, an interaction between USP7 and the EBNA1 protein of (EBV) (another ) was also discovered. This interaction is particularly interesting given the potential (potential to cause cancer) of EBV, which is associated with several human cancers. Samurai Warriors 2 Ost Rar Files. Peavey 5150 Serial Number Dating. EBNA1 can compete with p53 for binding USP7. Stabilization by USP7 is important for the tumor suppressor function of p53.

In cells, EBNA1 can sequester USP7 from p53 and thus attenuate stabilization of p53, rendering the cells predisposed to turning cancerous. Compromising the function of p53 by sequestering USP7 is one way EBNA1 can contribute to the potential of EBV.